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Raloxifene HCL Raloxifene hydrochloride 82640-04-8 Keoxifene Similar Tamoxifen Powder

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Zhuhaishi Shuangbojie Technology Co.,ltd
City: Zhuhai
Province/State: Guangdong
Country/Region: China
Tel: 86-18578209857
Contact Person:
Ms Rachel

Raloxifene HCL Raloxifene hydrochloride 82640-04-8 Keoxifene Similar Tamoxifen Powder

Brand Name : whatsapp: +8618578209857
Model Number : 82640-04-8
Certification : SGS,ISO9001,UKAS
Place of Origin : steroidraw@chembj.com
MOQ : 10g
Price : Negotiation
Payment Terms : Western Union, MoneyGram, T/T,Bitcoin
Supply Ability : 1000 Kilogram/Kilograms per Month
Delivery Time : within 12hours after payment
Packaging Details : Special disguised packaging or as your demand
Product name : raloxifene hcl, Raloxifene hydrochloride
CAS : 82640-04-8
Appearance : light yellow powder
Usage : antineoplastic
email : steroidraw@chembj.com
skype : racheltao5605
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99% Raloxifene HCL Raloxifene hydrochloride CAS:82640-04-8 Keoxifene Similar Tamoxifen Powder

1.
Raloxifene hydrochloride Quick detail:
Name:raloxifene hcl, Raloxifene hydrochloride
CAS No.:82640-04-8
MF:C28H28ClNO4S
Use:antineoplastic
Appearance:light yellow powder

2.
Raloxifene hydrochloride Description:
Evista (Raloxifene Hydrochloride) is an estrogen agonist/antagonist, referred to as a selective estrogen
receptor modulator (SERM) and belongs to the benzothiophene class of compounds. The biological
actions of Raloxifene are largely mediated through binding to estrogen receptors. This binding results in
activation of estrogenic pathways in some tissues (Agonism) and and the blockade of estrogenic
pathways in other tissues (Antagonism).
2. Why is this medication prescribed:
(1) Raloxifene is used to prevent and treat osteoporosis (condition in which the bones become thin and
weak and break easily) in women who have undergone menopause (change of life; end of menstrual
periods). Raloxifene is also used to decrease the risk of developing invasive breast cancer (breast
cancer that has spread outside of the milk ducts or lobules into the surrounding breast tissue) in women who are at high risk of developing this type of cancer or who have osteoporosis. Raloxifene cannot be
used to treat invasive breast cancer or to prevent invasive breast cancer from coming back in women
who have already had the condition.
(2) Raloxifene also cannot be used to decrease the risk of developing non-invasive breast cancer.
Raloxifene is in a class of medications called selective estrogen receptor modulators (SERMs).
Raloxifene prevents and treats osteoporosis by mimicking the effects of estrogen (a female hormone
produced by the body) to increase the density (thickness) of bone. Raloxifene decreases the risk of
developing invasive breast cancer by blocking the effects of estrogen on breast tissue. This may stop
the development of tumors that need estrogen to grow.
3. Use and Dose:
Evista is specifically approved for the treatment and prevention of osteoporosis in postmenopausal
women, the reduction in risk of invasive breast cancer in postmenopausal women with osteoporosis
and the reduction in risk of invasive breast cancer in postmenopausal women at high risk of invasive
breast cancer. Evista is supplied as a 60 mg tablet designed for oral administration. The recommended
initial dose of the drug is one 60 mg tablet daily, which may be administered any time of day without
regard to meals.


For bodybuilding purposes Adipex-P is often administered during the pre-contest phase of training.

When taken in conjunction with all the pre-contest principles that would be employed anyway, i. e.

Cardio and weight training exercise, behavioral modification, caloric restriction, increased protein consumption, etc., Adipex-P can be a great addition to the carbohydrate craving/depleted diet

regimen. The usual adult dose is one tablet (37.5 mg) daily, administered before breakfast or 1-2

hours after breakfast. Bodybuilder dosage recommendations are consistent with those of patients,

and should be individualized to obtain an adequate response with the lowest effective dose. For

some patients or bodybuilders half a tablet (18.75 mg) daily may be adequate, while others might

take half a dose twice daily. Raloxifene is a selective estrogen receptor modulator (SERM); acts as

an anti-estrogen in both breast and uterine tissue while being estrogenic in bone. May have efficacy against estrogen-sensitive cancers.


3.
Raloxifene hydrochloride Product Picture:


4.
Raloxifene hydrochloride Specification:

Product Name:

Raloxifene hydrochloride

CAS:

82640-04-8

MF:

C28H28ClNO4S

MW:

510.04

Product Categories:

Active Pharmaceutical Ingredients;Raloxifene;Intracellular
receptor;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;
Sulfur & Selenium Compounds;Pharmaceutical intermediate

Mol File:

82640-04-8.mol

mp

250-253°C

storage temp.

-20°C Freezer

solubility

DMSO: 28 mg/mL, soluble

form

solid

color

light yellow

CAS DataBase Reference

82640-04-8(CAS DataBase Reference)

Chemical Properties

Light-Yellow Solid

Usage

A nonsteroidal, selective estrogen receptor modulator (SERM).
Antiosteoporotic.


5. Raloxifene hydrochloride COA

TEST ITEMSSPECIFICATIONRESULTS
Description: White Crystalline PowderWhite Powder
Identification: PositivePositive
Assay(by HPLC): 98.0~102.0%99.64%
Absorbance(E1cm): 465~495482.5
Melting Point: 191~195°C193.5~195.0°C
Loss On Drying: 0.5%max0.19%
Specific Rotation: +288°~ +298°+290.2°
Residue On Ignition: 0.1%max0.03%
Related Substances: Total:1.5%max<1.3%
Single:0.5%max<0.4%
Residue Solvents: 0.2%max0.10%
Heavy Metals: 20PPm max<10PPm
ConclusionThe specification conform with enterprise standard.

6. Raloxifene hydrochloride Application:

May prevent or treat corticosteroid-induced bone loss. American College of Rheumatology states that raloxifene can be offered to selected postmenopausal corticosteroid-treated women who refuse

hormone replacement therapy or other antiresorptive agents (e. G., bisphosphonates, calcitonin) or

in whom such therapies are contraindicated.

Reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis.

Reduction in the incidence of invasive breast cancer in postmenopausal women at high risk for developing the disease. Effect comparable to that of tamoxifen in reducing the risk of invasive breast cancer (STAR trial). No effect on the risk of lobular carcinoma in situ or ductal carcinoma in situ

(STAR trial). Effect on breast cancer incidence in women with BRCA1 or BRCA2 genetic mutations not established.

Not indicated for the treatment of breast cancer or to reduce the risk of recurrence of breast cancer.

1 Not indicated for reduction in the risk of noninvasive breast cancer.

Side effect: Raloxifene may infrequently cause serious blood clots to form in the legs, lungs, or eyes. Other reactions experienced include leg swelling/pain, trouble breathing, chest pain, vision changes. Raloxifene is a teratogenic drug, i. e., can cause developmental abnormalities such as birth defects.


Reduction in the incidence of invasive breast cancer in postmenopausal women with osteoporosis.
in 2006, the National Cancer Institute announced that raloxifene was as effective as tamoxifen in reducing the incidence of breast cancer in postmenopausal women at increased risk,

EVISTA (raloxifene hydrochloride) is an estrogen agonist/antagonist, commonly referred to as a selective estrogen receptor modulator (SERM) that belongs to the benzothiophene class of compounds
The chemical designation , [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]-, hydrochloride. Raloxifene hydrochloride (HCl) has the empirical formula C28H27NO4S.HCl, which corresponds to a molecular weight of 510.05. Raloxifene HCl is an off-white to pale-yellow solid that is very slightly soluble in water.

EVISTA (raloxifene) is supplied in a tablet dosage form for oral administration. Each EVISTA tablet contains 60 mg of raloxifene HCl, which is the molar equivalent of 55.71 mg of free base. Inactive ingredients include anhydrous lactose, carnauba wax, crospovidone, FD&C Blue No. 2 aluminum lake, hypromellose, lactose monohydrate, magnesium stearate, modified pharmaceutical glaze, polyethylene glycol, polysorbate 80, povidone, propylene glycol, and titanium dioxide.


7. Advantage of Raloxifene Hydrochloride;CAS:82640-04-8 /Best price in China

(1) High quality

(2) Competitive price

(3) First-class service and product

(4) Environment friendly

(5) Great performance

(6) Easy application



8. Competitive Advantages:

Hello,Zhuhaishi Shuangbojie Technology Co.,ltd is a leading worldwide professional manufacture of
medications.We supply hundreds of different types of medications including testosterone,trenbolone,
nandrolone, ect.We ship through EMS with tracking numbers.
1. Rich experience.
We only send the HIGHEST purity Steroids, Peptides, Research chemicals & Pharmaceuticals which
are very popular in many countries.Our steroids and hormones have been exported to overseas, like
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2. Best price
Our prices are the best because of the discounts that we give to all our buyers. We give very good
discounts which makes our prices outstanding in the market.
3. Great quality, purity and favorable.
Genuine and 100% Guarantee on all orders you place. We Have the Best you will come across Online.
We, As well Provide Tracking on Packages as they are being sent.Our MOQ is 10grams,any trial order
is welcome,you can make decisions of committing to buying in bulk once our product has been tested.
4. Experiential shopping
Besides raw steroid powder and liquid, we offer hormone solution and formula. We can teach you how
to make hormone solution on the site. Any visit to our lab is welcomed.
5. Good after-sales service.
We will always send you top quality products with very competitive price,we as well offer best customer
service and excellent shipment ability,i wish you can email me and let me introduce my products for you.


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