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Trilostane CAS 13647-35-3 Vetoryl pharmaceutical raw material for Treatment

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Zhuhaishi Shuangbojie Technology Co.,ltd
City: Zhuhai
Province/State: Guangdong
Country/Region: China
Tel: 86-18578209857
Contact Person:
Ms Rachel

Trilostane CAS 13647-35-3 Vetoryl pharmaceutical raw material for Treatment

Brand Name : whatsapp: +8618578209857
Model Number : 13647-35-3
Certification : SGS,ISO9001,UKAS
Place of Origin : steroidraw@chembj.com
MOQ : 10g
Price : Negotiation
Payment Terms : Western Union, MoneyGram, T/T,Bitcoin
Supply Ability : 1000 Kilogram/Kilograms per Month
Delivery Time : within 12hours after payment
Packaging Details : Special disguised packaging or as your demand
Product name : Trilostane
CAS : 13647-35-3
MF : C20H27NO3
Molecular Weight : 329.43
Appearance : White powder
Usage : Can be used as pharmaceutical raw material
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Trilostane CAS 13647-35-3 Vetoryl pharmaceutical raw material for Treatment

1. Trilostane Quick detail:


Name


Trilostane

Synonyms


(4a,5a,17b)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile


Molecular Structure



Molecular Formula


C20H27NO3

Molecular Weight


329.43

CAS Registry Number


13647-35-3

EINECS


237-133-0


Product Name:Trilostane

CAS:13647-35-3

Molecular Formula:C20H27NO3

Molecular Weight:329.43

Assay:99%

Appearance:White or colourless crystalline powder with characteristic odor


2. Trilostane DESCRIPTION
Trilostane is an inhibitor of isoforms 3β-HSD and 3β-HSD2 of the enzyme 3β-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg

195 in 3β-HSD versus Pro195 in 3β-HSD2 attributes to the competitive inhibition of 3β-HSD, but not

3β-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular

production of androstenedione, testosterone, and dihydrotestosterone in LNCaP-FGC prostate

cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves

as a useful tool in steroid biosynthesis research.


3. Trilostane Product Picture:

4. Trilostane Application:
Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make
cortisol, aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome
(cortisol increase disease) and primary aldosteronism,the effect is not good than testosterone
metyrapone. This product has significantly reduced blood testosterone level role, may relevant

to its inhibit synthetic.

Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.

Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting

this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause

problems. Trilostane reduces the amount of steroids produced by the adrenal gland.

Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids

by 3-beta-hydroxysteroid dehydrogenase/delta 5, 4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

Side effect: Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.


5. Trilostane Main function:

Trilostane can suppress cortical hormone synthesis process of 3 beta dehydrogenase, make cortisol, aldosterone synthesis reduce, clinical used in the treatment of Cushing syndrome(cortisol increase disease) and primary aldosteronism,the effect is not good than testosterone metyrapone. This product has significantly reduced blood testosterone level role, may relevant to its inhibit synthetic.


6. Trilostane Specification:

Test Item

Analysis Specification

Result

Description

White to off-white power

Conforms

Purity

98.5%min

99.20%

Water(K.F)

≤0.5%

0.20%

Loss on drying

≤0.5%

0.26%

Residue on ignition

≤0.1%

0.04%

Heavy metals

≤20ppm

<20ppm

Specific optional rotation

+137°~ +139°

+138.8°

Conclusion

Conform to Company Standard.


Product NameTrilostane
Batch No.14121501Mfg. date2014-12-15
Test Date2014-12-25Exp. date2016-12-14
TestsSpecificationsResults
DescriptionWhite to yellowish powder, very hygroscopic.Off-white powder, very hygroscopic.
SolubilityFreetly soluble In water and methanol and dichloromethaneComplies
Identification(1)By IR, To match with working standardComplies
(2)It gives reaction of sodiumComplies
Impurities A≤0.1%Not detected
Related compoundsAny impurity ≤0.1%<0.1%
Total impurities ≤0.4%0.25%
Residual SolventsAcetidin≤ 0.5%Not detected
Dichloromethane≤ 0.06%Not detected
Methanol≤ 0.3%Not detected
Acetone ≤ 0.5%Not detected
Acetonitrile≤0.041%Not detected
Ethanol≤0.5%0.04%
N, N-dimethylformamide≤0.088%Not detected
Water≤ 5.0%1.38%
Assay99.0%-101.0%(On anhydrous basis)99.98%
ConclusionConform to EP8.0

7. Packing & Storage

Packaging Detail

0.5kgs/Al-foil bag

1.0kgs/Al-foil bag

2.0kgs/Al-foil bag

5.0 kgs/Al-foil bag

25.0 kgs/drum

or upon customers' request.

StorageStore in a well-closed container away from moisture
Shelf Life2 years if sealed and store away from direct sun light.
Delivery Detail

within 3 days after get the payment


8. Competitive Advantages:

Hello,Zhuhaishi Shuangbojie Technology Co.,ltd is a leading worldwide professional manufacture of
medications.We supply hundreds of different types of medications including testosterone,trenbolone,
nandrolone, ect.We ship through EMS with tracking numbers.
1. Rich experience.
We only send the HIGHEST purity Steroids, Peptides, Research chemicals & Pharmaceuticals which
are very popular in many countries.Our steroids and hormones have been exported to overseas, like
USA, Canada,UK,Brazil,Netherlands, Ireland, New Zealand, Austria, Australia and so on.And we have
got very good feedback from our customers, and established long friendly relations of cooperation.
2. Best price
Our prices are the best because of the discounts that we give to all our buyers. We give very good
discounts which makes our prices outstanding in the market.
3. Great quality, purity and favorable.
Genuine and 100% Guarantee on all orders you place. We Have the Best you will come across Online.
We, As well Provide Tracking on Packages as they are being sent.Our MOQ is 10grams,any trial order
is welcome,you can make decisions of committing to buying in bulk once our product has been tested.
4. Experiential shopping
Besides raw steroid powder and liquid, we offer hormone solution and formula. We can teach you how
to make hormone solution on the site. Any visit to our lab is welcomed.
5. Good after-sales service.
We will always send you top quality products with very competitive price,we as well offer best customer
service and excellent shipment ability,i wish you can email me and let me introduce my products for you.


Product Tags:

Pharmaceutical Powder

      

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