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Lioresal Baclofen Alcoholism Treatment GABA Baclofen CAS 1134-47-0

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Lioresal Baclofen Alcoholism Treatment GABA Baclofen CAS 1134-47-0

Brand Name : whatsapp: +8618578209857
Model Number : Baclofen
Certification : ISO; SGS
Place of Origin : steroidraw@chembj.com
MOQ : 10g
Price : USD1/10g~USD100/10g
Payment Terms : Western Union, MoneyGram, T/T,Bitcoin
Supply Ability : plent of stock
Delivery Time : within 12hours after payment
Packaging Details : Special disguised packaging or as your demand
Product name : Baclofen
Other name : Baclofen
CAS Number : 1134-47-0
M.F. : C10H12ClNO2
M.W. : 213.66
Packaging : foil bag or vial
Appearance : white powder
Assays : 99%
Shipping : by express (FedEx,UPS,DHL,EMS), by air and by sea
Payment : Western Union, Money Gram, T/T and Paypal
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Lioresal Baclofen Alcoholism Treatment GABA Baclofen CAS 1134-47-0


1. Baclofen quick detail:

Product Name: Baclofen
Tag: gamma-aminobutyric acid, GABA, Kemstro,Lioresal,Liofen,Gablofen,Lyflex,Beklo,Baclosan

Synonym Kemstro,Lioresal,Liofen,Gablofen,Lyflex,Beklo,Baclosan

CAS 1134-47-0

MF C10H12ClNO2

MW 213.66

EINECS 214-486-9

Assay 99%

Quality Standards Enterprise Standard/Pharma Grade

Appearance White powder

Package 25kg/Drum

Place of Origin China

Certification ISO9001, ISO14000, KOSHER

Model Number 1134-47-0

MOQ 1 kg

Packaging Details 25kg/Drum, 1kg/bag

Delivery Time 1-2 days

Payment Terms T/T, Western union, Money gram

Supply Ability 500000 T/Month


2. Baclofen description:

(1) Baclofen (brand names Kemstro, Lioresal, Liofen, Gablofen, Lyflex, Beklo and Baclosan) is a derivative of gamma-aminobutyric acid (GABA). It is primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism. It is also used by compounding pharmacies in topical pain creams as a muscle relaxant.

(2) It is an agonist for the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups.

(3)A beneficial property of baclofen is that tolerance does not seem to occur to a significant degree - baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use. Newer studies, however, indicate that tolerance may develop in some patients receiving intrathecal baclofen treatment. 3. Medical uses: Baclofen is primarily used for the treatment of spastic movement disorders, especially in instances of spinal cord injury, cerebral palsy, and multiple sclerosis. Its use in people with stroke or Parkinson's disease is not recommende. 4. Mechanism of action: Baclofen produces its effects by activating the GABAB receptor, similar to the drug which also activates this receptor and shares some of its effects. However, baclofen does not have significant affinity for the receptor, and has no known abuse potential. The modulation of the GABAB receptor is what produces baclofen's range of therapeutic properties.


3. Baclofen Specifications:


Items Tested

Specification

Result

Characters

A white, crystalline powder or colorless crystals.

A white crystal.

Identification

IR should comply with the Reference Standard spectrum.
UV should comply with the Reference Standard spectrum.
An orange-red precipitate is performed.

IR complies with the Reference standard spectrum.
UV complies with the Reference standard spectrum.
An orange-red precipitate is performed.

Melting range

88 ~92 degree

89.8-90.2degree

Loss on Drying

Not more than 1.0%

0.22%

Readily carbonizable Substances

The resolution has no more color than Matching Fluid A.

Conform

Residue on ignition

Not more than 0.1%

0.02%

Heavy metals

Not more than 0.001%

Conform

Chloride

Conform

Conform

Assay (HPLC)

98.0%-102.0%

99.5%

Ordinary Impurities

≤1%

Conform

Reaction

Conform

Conform

Conclusion

Complies to USP31

ITEMSSTANDARDSRESULTSMETHODS
AppearanceWhite to almost white crystalline powderConformsOrganoleptic
IdentificationIR or HPLCPositiveUSP
Water contentNMT3.0%0.17%USP
Residue on IgnitionNMT0.3%0.05%USP
Heavy MetalsNMT10.0ppmNMT10.0ppmUSP
Assay98.0%~102.0%99.20%HPLC
Impurity ANMT1.0%NegativeHPLC
Any Individual ImpuritiesNMT0.1%0.02%HPLC
Total ImpuritiesNMT2.0%0.02%HPLC
ConclusionThe product conforms to the current USP.

4. Baclofen Function:

Baclofen powder can be used as Specific GABA-B receptor agonist. Muscle relaxant (skeletal). It is primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism. In addition, research has shown baclofen to be effective in the treatment of alcohol dependence and withdrawal, by inhibiting both withdrawal symptoms and cravings.


5. Baclofen Application:

Baclofen powder also known as β-(4-chlorophenyl)-γ-aminobutyric acid (β-(4-chlorophenyl)-GABA), used as a skeletal muscle relaxant. It is primarily used to treat spasticity. It is also used by compounding pharmacies in topical pain creams as a muscle relaxant.

It is a GABA receptor agonist, specifically of the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. It is a derivative of γ-aminobutyric acid (GABA).

A beneficial property of baclofen is that tolerance to its muscle-related therapeutic benefits does not seem to occur to a significant degree — baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use. Newer studies, however, indicate that tolerance may develop in some people receiving intrathecal baclofen treatment.



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